Non-steroidal anti-inflammatory drugs often used as Painkiller


Some of you may already be familiar with some medications that are often prescribed or sold free as pain medications like ibuprofen or aspirin. Did you what is the type of both drugs and how does it work and its trademark?

Ibuprofen and aspirin are part of a non Steroidal anti-inflammatory drug type or also known as Non-steroid Anti-function Drugs or NSAIDs. Drug types of NSAIDS include a heterogeneous type, even each type has a different chemical arrangement with one another. The similarity of this type of medicine is its function as an anti-inflammatory to overcome inflammation, antipyretic to normalize body temperature and analgesic function for a pain reliever.

Non-steroidal mention is a differentiator with other anti-inflammatory types that are steroids. The fundamental difference between the forms of anti-inflammatory steroids with nonsteroids lies in how it works. This type of steroid tends to be premature in preventing body pain responses so that it is suitable for any type of trauma or heavier tissue damage. While the non-steroidal type is more superficial and suitable for the type of wounds and more mild trauma.



The mechanism of action of non-steroidal anti-inflammatory drugs focuses on inhibition of the Isoenzyme COX-1 (cyclooxygenase-1) and COX-2 (cyclooxygenase-2). This enzimcyclooxygenase has a role in encouraging the process of forming prostaglandins and thromboxanes from arachidonic acid. For you know the prostaglandins are an important molecule in the process of traumatic message-making to the brain and nerve sensors in the inflammatory process (inflammation).

By nurturing NSAIDs, patients with trauma or wound conditions, inner and outer irritation, as well as inflammation of either the skin surface or within the surface of the skin will be able to relieve the pain they feel or become an analgesic function.

In addition to helping to dampen the pain by manipulating the production of the traumatic signal evasion enzyme, non-steroidal anti-inflammatory drugs can also work as anti-pyretic. Anti-Pyretic is a function to help overcome the rise of body temperature.

Usually, in conjunction with inflammatory or inflammation, a fever will appear on various scales. This fever is a natural reaction to the body's increase in immune system work against inflammation. It is a reaction adaptation because the process of increased immunity performance will boost the increase or induction of body temperature.

NSAIDs will work by affecting the hypothalamus in response to signals from interleukins in inducing body temperature. It also deals with the function of NSAIDS in suppressing the production of prostaglandins. Usually, the way to perform an antipyretic function is to push the blood flow towards the peripheral and trigger a sweating body to adapt the body temperature high back down.

Non-Steroidal anti-inflammatory drugs in the pharmaceutical world itself are divided into several types. And types will be explained as follows.


Salicylates

Work overcoming inflammation and infection by alleviating the symptoms that arise, but not addressing the main problem, but only overcoming the form of inflammation that appears such as swelling, bruising effect, pain, and red hue due to inflammation.

The types included in this group include aspirin or acetylsalicylic acid, methyl salicylates, magnesium salicylates, salicylates, and Salicilamides. This type of NSAIDS is also effective to help relieve inflamed acne, blood clotting complaints, so it is also effective for heart complaints and stroke.

Arilalkanoat acid Group

Included in this type of medicine are diclofenac, indomethacin, Proglumetasin, and Oksametasin. Working in the same way as other non-steroidal anti-inflammatory drugs, this type also works triple as anti-analgesic, anti-inflammatory, and anti-pyretic. Regular work for muscle tension and nerve problems that trigger pain effects such as migraine and neck pain.

The Proven

These types may include familiar types, such as ibuprofen, Alminoprofen, Fenbufen, Indoprofen, naproxen, and Ketorolac . Its nature works quite quickly, because of its ability to be easily digested in the stomach.

Perizolidin

This type can be found on the market in the form of Enilbutazon, Ampiron, Metamizole, and Amazon. This type is not very prevalent in local medicine in Indonesia, but it is quite commonly known as anti-rheumatic in various countries in the European hemisphere. But later Metamizole is also often prescribed in the treatment of rheumatism and uric acid.


Oxythand

You may also be familiar with the analgesic medications most commonly prescribed in rheumatic and gout treatment. It is also often a remedy for you who are experiencing severe analgesic aches. It contains drowsiness effects that make it unsuitable for you who drive.

The format or N-Arilantranylic acid Group

This type is commonly used to help relieve pain caused by muscle tension, muscle and nerve contractions such as headaches, migraine, and painful menstruation. Usually, you come across in the form of mefenamic acid, flufenamic acid, and tolfenamat acid.

Other classes

Many other types of non-steroidal anti-inflammatory drugs also work in the same way but in a wide variety of conditions. Call it acetaminophen or paracetamol, lifelong or nimesulide.
In general, the function of non-steroidal anti-inflammatory drugs is as a reliever of any kind of pain. Starting from pain in the area of the muscles due to the effects of acute inflammation such as rheumatism, arthritis, gout, carpal syndrome, nerve clasps, and so forth. It is also effective to help overcome joint pains due to sprains, great analgesic aches, and so on.

But this type of medicine can also work effectively to relieve headaches, pain due to treatment such as pain due to immunization injections or painful menstruation. Of course, not all medications can be used for any type of complaint.

Non-steroidal anti-inflammatory drugs, in general, are harmless, of course during consumption with safe dosages. Because there are two risks of side effects of taking this type of medication especially when you are consuming it excessively or in the long term.

Two commonly emerging side effects are peptic diseases and nausea that can arise due to the effect of the inhibitory process of prostaglandins which has benefits in gastric function. Also, kidney problems can arise due to the effect of the excessive oscillations of this type of drug and precipitated in the kidneys. Some cases may also elicit platelet defects.

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